Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics.

ABSTRACT: Hepatitis B virus (HBV) infection kinetics in immunodeficient mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive immune response. To recapitulate the multiphasic viral kinetic patterns, we developed an agent-based model that includes intracellular virion production cycles reflecting the cyclic nature of each individual virus lifecycle. The model fits the data well predicting an increase in production cycles initially starting with a long production cycle of 1 virion per 20 hours that gradually reaches 1 virion per hour after approximately 3-4 days before virion production increases dramatically to reach to a steady state rate of 4 virions per hour per cell. Together, modeling suggests that it is the cyclic nature o

SUBMITTER: Hailegiorgis A 

PROVIDER: S-EPMC10426918 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature