Long term prophylactic anticoagulation for portal vein thrombosis after splenectomy: A systematic review and meta-analysis.

ABSTRACT:

Aim

The aim of this study was to evaluate the efficacy and safety of the anticoagulants for the prevention of portal vein system thrombosis (PVST) in patients with cirrhosis after splenectomy and explore the optimal time of anticoagulant administration.

Methods

A systematic literature search was performed using PubMed, Embase and China Biology Medicine disc (CBM)databases, so as to screen out studies comparing the prognoses between cirrhotic post-splenectomy patients treated with and without anticoagulants. The parameters that were analyzed included the incidence of PVST and postoperative bleeding.

Results

With a total of 592 subjects, we included 8 studies (6 observational and 2 randomized trials) that fulfilled the inclusion criteria. We found that the incidence of

SUBMITTER: Liao Z 

PROVIDER: S-EPMC10426921 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature