Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns.

ABSTRACT: Previous studies have described the association of onchocerciasis (caused by Onchocerca volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still missing. Cases are found in different African countries (Tanzania, South Sudan, Uganda, Democratic Republic of the Congo, Central African Republic and Cameroon). In our study we investigated immunological parameters (cytokine, chemokine, immunoglobulin levels) in individuals from the Mahenge area, Tanzania, presenting with either epilepsy or nodding syndrome with or without O. volvulus infection and compared them to O. volvulus negative individuals from the same endemic area lacking neurological disorders. Additionally, cell differentiation was performed using blood smears and systemic levels of neurodegenera

SUBMITTER: Arndts K 

PROVIDER: S-EPMC10426931 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature