Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure.

ABSTRACT: The thalamus is a central brain structure that serves as a relay station for sensory inputs from the periphery to the cortex and regulates cortical arousal. Traditionally, it has been regarded as a passive relay that transmits information between brain regions. However, recent studies have suggested that the thalamus may also play a role in shaping functional connectivity (FC) in a task-based context. Based on this idea, we hypothesized that due to its centrality in the network and its involvement in cortical activation, the thalamus may also contribute to resting-state FC, a key neurological biomarker widely used to characterize brain function in health and disease. To investigate this hypothesis, we constructed ten in-silico brain network models based on neuroimaging data (MEG, MRI, and

SUBMITTER: Cabrera-Alvarez J 

PROVIDER: S-EPMC10426958 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature