Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression.

ABSTRACT: In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input polarization-sensitive OCT may help establish post

SUBMITTER: Liu X 

PROVIDER: S-EPMC10427432 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature