Proton pump inhibitor use: systematic review of global trends and practices.

ABSTRACT:

Purpose

Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and rank as one of the most widely used acid-suppressing medicines globally. While PPIs are safe in the short-term, emerging evidence shows risks associated with long-term use. Current evidence on global PPI use is scarce. This systematic review aims to evaluate global PPI use in the general population.

Methods

Ovid MEDLINE, Embase, and International Pharmaceutical Abstracts were systematically searched from inception to 31 March 2023 to identify observational studies on oral PPI use among individuals aged ≥ 18 years. PPI use was classified by demographics and medication factors (dose, duration, and PPI types). The absolute numbers of PPI users for each subcategory were summed and expressed as a perce

SUBMITTER: Shanika LGT 

PROVIDER: S-EPMC10427555 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature