Propionic acid induces alterations in mitochondrial morphology and dynamics in SH-SY5Y cells.

ABSTRACT: Propionic acid (PPA) is used to study the role of mitochondrial dysfunction in neurodevelopmental conditions like autism spectrum disorders. PPA is known to disrupt mitochondrial biogenesis, metabolism, and turnover. However, the effect of PPA on mitochondrial dynamics, fission, and fusion remains challenging to study due to the complex temporal nature of these mechanisms. Here, we use complementary quantitative visualization techniques to examine how PPA influences mitochondrial ultrastructure, morphology, and dynamics in neuronal-like SH-SY5Y cells. PPA (5 mM) induced a significant decrease in mitochondrial area (p < 0.01), Feret's diameter and perimeter (p < 0.05), and in area² (p < 0.01). Mitochondrial event localiser analysis demonstrated a significant increase in fission a

SUBMITTER: Buchanan E 

PROVIDER: S-EPMC10427685 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature