Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood.

ABSTRACT:

Introduction

The proportion of older adults within society is sharply increasing and a better understanding of how we age starts to be critical. However, given the paucity of longitudinal studies with both neuroimaging and epigenetic data, it remains largely unknown whether the speed of the epigenetic clock changes over the life course and whether any such changes are proportional to changes in brain aging and cognitive skills. To fill these knowledge gaps, we conducted a longitudinal study of a prenatal birth cohort, studied epigenetic aging across adolescence and young adulthood, and evaluated its relationship with brain aging and cognitive outcomes.

Methods

DNA methylation was assessed using the Illumina EPIC Platform in adolescence, early and late 20 s, DNA methylation a

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC10427722 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature