Re-examining baseline lung function recovery following IV-treated pulmonary exacerbations.

ABSTRACT: CF registry pulmonary exacerbation (PEx) analyses have employed "before and after" spirometry recovery, where the best percent predicted forced expiratory volume in 1 s (ppFEV₁) prior to PEx ("baseline") is compared to the best ppFEV₁ <3 months post-PEx. This methodology lacks comparators and ascribes recovery failure to PEx. Herein, we describe 2014 CF Foundation Patient Registry PEx analyses including a comparator: recovery around nonPEx events, birthdays. 49.6% of 7357 individuals with PEx achieved baseline ppFEV₁ recovery while 36.6% of 14,141 achieved baseline recovery after birthdays; individuals with both PEx and birthdays were more likely to recover baseline after PEx than after birthdays (47% versus 34%); mean ppFEV₁ declines were 0.3 (S

SUBMITTER: Heltshe SL 

PROVIDER: S-EPMC10427727 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature