Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk.

ABSTRACT:

Introduction

Apolipoprotein E (APOE) ε4-carrier status or ε4 allele count are included in analyses to account for the APOE genetic effect on Alzheimer's disease (AD); however, this does not account for protective effects of APOE ε2 or heterogeneous effect of ε2, ε3, and ε4 haplotypes.

Methods

We leveraged results from an autopsy-confirmed AD study to generate a weighted risk score for APOE (APOE-npscore). We regressed cerebrospinal fluid (CSF) amyloid and tau biomarkers on APOE variables from the Wisconsin Registry for Alzheimer's Prevention (WRAP), Wisconsin Alzheimer's Disease Research Center (WADRC), and Alzheimer's Disease Neuroimaging Initiative (ADNI).

Results

The APOE-npscore explained more variance and provided a better model fit for all three CSF measures tha

SUBMITTER: Deming Y 

PROVIDER: S-EPMC10427737 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature