Heterogeneous biological membranes regulate protein partitioning via fluctuating diffusivity.

ABSTRACT: Cell membranes phase separate into ordered Lo and disordered Ld domains depending on their compositions. This membrane compartmentalization is heterogeneous and regulates the localization of specific proteins related to cell signaling and trafficking. However, it is unclear how the heterogeneity of the membranes affects the diffusion and localization of proteins in Lo and Ld domains. Here, using Langevin dynamics simulations coupled with the phase-field (LDPF) method, we investigate several tens of milliseconds-scale diffusion and localization of proteins in heterogeneous biological membrane models showing phase separation into Lo and Ld domains. The diffusivity of proteins exhibits temporal fluctuations depending on the field composition. Increases in molecular concentrations and domain p

SUBMITTER: Sakamoto K 

PROVIDER: S-EPMC10427746 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature