Mendelian randomization analyses support causal relationship between gut microbiota and childhood obesity.

ABSTRACT:

Background

Childhood obesity (CO) is an increasing public health issue. Mounting evidence has shown that gut microbiota (GM) is closely related to CO. However, the causal association needs to be treated with caution due to confounding factors and reverse causation.

Methods

Data were obtained from the Microbiome Genome Consortium for GM as well as the Early Growth Genetics Consortium for childhood obesity and childhood body mass index (CBMI). Inverse variance weighted, maximum likelihood, weighted median, and MR.RAPS methods were applied to examine the causal association. Then replication dataset was used to validate the results and reverse Mendelian randomization analysis was performed to confirm the causal direction. Additionally, sensitivity analyses including Cochran's

SUBMITTER: Li Q 

PROVIDER: S-EPMC10427879 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature