Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder.

ABSTRACT:

Background

Unravelling the relationships between candidate genes and autism spectrum disorder (ASD) phenotypes remains an outstanding challenge. Endophenotypes, defined as inheritable, measurable quantitative traits, might provide intermediary links between genetic risk factors and multifaceted ASD phenotypes. In this study, we sought to determine whether plasma metabolite levels could serve as endophenotypes in individuals with ASD and their family members.

Methods

We employed an untargeted, high-resolution metabolomics platform to analyse 14,342 features across 1099 plasma samples. These samples were collected from probands and their family members participating in the Autism Genetic Resource Exchange (AGRE) (N = 658), compared with neurotypical individuals enrolled in the

SUBMITTER: Lee IH 

PROVIDER: S-EPMC10427990 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature