Cu-HKUST-1 and Hydroxyapatite-The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration.

ABSTRACT: A novel composite based on biocompatible hydroxyapatite (HA) nanoparticles and Cu-HKUST-1 (Cu-HKUST-1@HA) has been prepared following a layer-by-layer strategy. Cu-HKUST-1 was carefully selected from a group of four Cu-based metal-organic frameworks as the material with the most promising antimicrobial activity. The formation of a colloidal Cu-HKUST-1 layer on HA nanoparticles was confirmed by various techniques, e.g., infrared spectroscopy, powder X-ray diffraction, N₂ sorption, transmission electron microscopy imaging, electron paramagnetic resonance, and X-ray absorption spectroscopy. Importantly, such a Cu-HKUST-1 layer significantly improved the nanomechanical properties of the composite, with Young's modulus equal to that of human cortical bone (13.76 GPa). At the s

SUBMITTER: Fandzloch M 

PROVIDER: S-EPMC10428089 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature