Selective synthesis of meta-phenols from bio-benzoic acids via regulating the adsorption state.

ABSTRACT: Phenols are important building blocks widely applied in many fields. The pronounced orientational effect of the phenolic hydroxyl group makes achieving selective synthesis of meta-phenols challenging. Accessing meta-phenols needs lengthy synthetic sequences. Herein, we first developed a heterogeneous CO₂-mediated CeO₂-5CuO catalyst for decarboxylative oxidation of benzoic acids with a more than 80% selectivity to meta-phenols. This technology is based on a traceless directing group relay method. The CeO₂-CuO catalysts with different Ce/Cu ratios exhibited controllable reaction selectivity between decarboxylation and decarboxylative oxidation. Spectroscopy experiments and computational studies showed the adsorption state of benzoic acid

SUBMITTER: Du X 

PROVIDER: S-EPMC10428116 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature