Teleost IgD⁺IgM^- B cells in gills and skin have a plasmablast profile, but functionally and phenotypically differ from IgM⁺IgD^- B cells in these sites.

ABSTRACT: Although most B cells in teleost systemic compartments co-express IgM and IgD on the surface, cells exclusively expressing either of the two Igs are common in fish mucosal tissues, providing us with a unique opportunity to further characterize IgD⁺IgM^- B cells, an intriguing B cell subset. Hence, we compared the phenotype of IgD⁺IgM^- cells to that of IgM⁺IgD^- B cells in rainbow trout gills and skin, also establishing the response of these subsets to immune stimulation. The transcriptional profile and secreting capacity of IgD⁺IgM^- B cells corresponded to that of cells that have started a differentiation program toward plasmablasts, similarly to IgM⁺IgD^- B cells. Yet, IgM⁺

SUBMITTER: Herranz-Jusdado JG 

PROVIDER: S-EPMC10428129 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature