Plug-and-Play Biointerfaces: Harnessing Host-Guest Interactions for Fabrication of Functional Polymeric Coatings.

ABSTRACT: Polymeric surface coatings capable of effectively integrating desired functional molecules and ligands are attractive for fabricating bio-interfaces necessary for various applications. Herein, we report the design of a polymeric platform amenable to such modifications in a modular fashion through host-guest chemistry. Copolymers containing adamantane (Ada) moieties, diethylene glycol (DEG) units, and silyloxy groups to provide functionalization handles, anti-biofouling character, and surface attachment, respectively, were synthesized. These copolymers were employed to modify silicon/glass surfaces to enable their functionalization using beta-cyclodextrin (βCD) containing functional molecules and bioactive ligands. Moreover, surface functionalization could be spatially controlled using a we

SUBMITTER: Degirmenci A 

PROVIDER: S-EPMC10428160 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature