Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.

ABSTRACT:

Background

Neuroendocrine tumors (NETs) early diagnosis is a clinical challenge that require a deep understanding of molecular and genetic features of this heterogeneous group of neoplasms. However, few biomarkers exist to aid diagnosis and to predict prognosis and treatment response. In the oncological field, tumor-educated platelets (TEPs) have been implicated as central players in the systemic and local responses to tumor growth, thereby altering tumor specific RNA profile. Although TEPs have been found to be enriched in RNAs, few studies have investigated the potential of a type of RNA, circular RNAs (circRNA), as platelet-derived biomarkers for cancer. In this proof-of-concept study, we aim to demonstrate whether the circRNAs signature of tumor educated platelets can be used a

SUBMITTER: Campolo F 

PROVIDER: S-EPMC10428534 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature