A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs.

ABSTRACT:

Background

Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses.

Methods

This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs.

Results

A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing act

SUBMITTER: Haach V 

PROVIDER: S-EPMC10428566 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature