Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile.

ABSTRACT:

Background

Clonorchiasis remains a non-negligible global zoonosis, causing serious socioeconomic burdens in endemic areas. Clonorchis sinensis infection typically elicits Th1/Th2 mixed immune responses during the course of biliary injury and periductal fibrosis. However, the molecular mechanism by which C. sinensis juvenile initially infects the host remains poorly understood.

Methods

The BALB/c mouse model was established to study early infection (within 7 days) with C. sinensis juveniles. Liver pathology staining and observation as well as determination of biochemical enzymes, blood routine and cytokines in blood were conducted. Furthermore, analysis of liver transcriptome, proteome and metabolome changes was performed using multi-omics techniques. Statistical analyses wer

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10428567 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature