Multi-target regulatory mechanism of Yang Xin Tang - a traditional Chinese medicine against dementia.

ABSTRACT:

Background

Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia. As the underlying mechanism of action of YXT has not been elucidated, we examined the effects of YXT and its major herbal components in regulating gene transcription and molecular targets related to Alzheimer's disease (AD).

Methods

Aqueous and ethanol extracts of YXT and selected herbal components were prepared and validated by standard methods. A series of biochemical and cellular assays were employed to assess the ability of the herbal extracts to inhibit acetylcholinesterase, reduce β-amyloid aggregation, stimulate the differentiation of neural progenitor cells, suppress cyclooxygenase, and protect neurons

SUBMITTER: Lo TY 

PROVIDER: S-EPMC10428601 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature