HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function.

ABSTRACT:

Background

Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropathic pain and motor dysfunction. Hyperbaric oxygen therapy (HBOT) has been suggested as a potential therapeutic tool for neuropathic pain and nerve injury. However, the specific cellular and molecular mechanism by which HBOT modulates the development of neuropathic pain and motor dysfunction through mitochondrial protection is still unclear.

Methods

Mechanical and thermal allodynia and motor function were measured in rats following sciatic nerve crush (SNC). The HBO treatment (2.5 ATA) was performed 4 h after SNC and twice daily (12 h intervals) for seven cons

SUBMITTER: Awad-Igbaria Y 

PROVIDER: S-EPMC10428612 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature