Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.

ABSTRACT:

Background

Complex immune-brain interactions that affect neural development, survival and function might have causal and therapeutic implications for psychiatric illnesses. However, previous studies examining the association between immune inflammation and schizophrenia (SCZ) have yielded inconsistent findings.

Methods

Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the causal association between immune cell signatures and SCZ in this study. Based on publicly available genetic data, we explored causal associations between 731 immune cell signatures and SCZ risk. A total of four types of immune signatures (median fluorescence intensities (MFI), relative cell (RC), absolute cell (AC), and morphological parameters (MP)) were included. C

SUBMITTER: Wang C 

PROVIDER: S-EPMC10428653 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature