Heart rate reduction after genetic ablation of L-type Ca_v1.3 channels induces cardioprotection against ischemia-reperfusion injury.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. Developing drugs that selectively reduce heart rate by inhibiting ion channels involved in heart rate control could provide more clinical benefits. The Ca_v1.3-mediated L-type Ca²⁺ current (I_Cav1.3) play important roles in the generation of heart rate. Therefore, they can constitute relevant targets for selective control of heart rate and cardioprotection during AMI.

Objective

We aimed to investigate the relationship between heart rate and infarct size using mouse strains knockout for Ca

SUBMITTER: Delgado-Betancourt V 

PROVIDER: S-EPMC10429177 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature