RNA conformational propensities determine cellular activity.

ABSTRACT: Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes¹. These interactions are mediated by intermolecular contacts, which if disrupted, lead to alterations in cell physiology. Nevertheless, the formation of intermolecular contacts nearly universally requires changes in the conformations of the interacting biomolecules. As a result, binding affinity and cellular activity crucially depend both on the strength of the contacts and on the inherent propensities to form binding-competent conformational states^2,3. Thus, conformational penalties are ubiquitous in biology and must be known in order to quantitatively model binding energetics for protein and nucleic acid interactions^4,5. However,

SUBMITTER: Ken ML 

PROVIDER: S-EPMC10429349 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature