Ketamine for the treatment of major depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Intranasal esketamine has received regulatory approvals for the treatment of depression. Recently a large trial of repeated dose racemic ketamine also demonstrated efficacy in severe depression. However, uncertainties remain regarding comparative efficacy, dosage, and the time course of response.

Methods

In this systematic review and meta-analysis, we searched Embase, Medline, Pubmed, PsycINFO, and CENTRAL up to April 13, 2023, for randomised controlled trials (RCTs) investigating ketamine for depression. Two investigators independently assessed study eligibility and risk of bias and extracted the data on depression severity scores, response and remission rates, and all-cause dropouts. Multivariable mixed-effects meta-regressions incorporated drug formulation (rac

SUBMITTER: Nikolin S 

PROVIDER: S-EPMC10430179 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature