From monomer to micelle: a facile approach to the multi-step synthesis of block copolymers via inline purification.

ABSTRACT: A one-pass continuous flow strategy to form block copolymer nanoaggregates directly from monomers is presented. A key development towards such a sophisticated continuous flow setup is a significant improvement in continuous flow dialysis. Often impurities or solvent residues from polymerizations must be removed before block extensions or nanoaggregate formation can be carried out, typically disrupting the workflow. Hence, inline purification systems are required for fully continuous operation and eventual high throughput operation. An inline dialysis purification system is developed and exemplified for amphiphilic block copolymer synthesis from thermal and photoiniferter reversible addition fragmentation chain transfer (RAFT) polymerization. The inline dialysis system is found to be signif

SUBMITTER: Voorter PJ 

PROVIDER: S-EPMC10430632 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature