Impact of perioperative inflammation on days alive and at home after surgery.

ABSTRACT:

Background

Perioperative inflammation is associated with perioperative complications, including delirium, that are associated with a reduced number of postoperative days alive and at home at 90 days (DAH90). We tested whether inflammation was associated with DAH90 even when adjusting for perioperative factors, and whether inflammation independently was associated with DAH90 when adjusting for delirium.

Methods

We conducted a prospective cohort study of major, non-intracranial surgical patients who were older than 65 yr (n=134). We measured postoperative delirium incidence and severity, and changes in interleukin (IL)-8 and IL-10 in blood plasma. Our primary outcome, DAH90, was analysed using quantile regression.

Results

Before adjusting for delirium, a postoper

SUBMITTER: Kunkel D 

PROVIDER: S-EPMC10430844 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature