Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine: a randomised controlled trial using tandem mass spectrometry.

ABSTRACT:

Background

This exploratory study aimed to investigate whether dexmedetomidine, propofol, sevoflurane, and S-ketamine affect oxylipins and bile acids, which are functionally diverse molecules with possible connections to cellular bioenergetics, immune modulation, and organ protection.

Methods

In this randomised, open-label, controlled, parallel group, Phase IV clinical drug trial, healthy male subjects (n=160) received equipotent doses (EC₅₀ for verbal command) of dexmedetomidine (1.5 ng ml^-1; n=40), propofol (1.7 μg ml^-1; n=40), sevoflurane (0.9% end-tidal; n=40), S-ketamine (0.75 μg ml^-1; n=20), or placebo (n=20). Blood samples for tandem mass spectrometry were obtained at baseline, after

SUBMITTER: Nummela A 

PROVIDER: S-EPMC10430865 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature