Combination of antidepressants and antipsychotics as a novel treatment option for psychosis in Alzheimer's disease.

ABSTRACT: Psychotic symptoms are reported as one of the most common complications of Alzheimer's disease (AD), in whom they are associated with more rapid deterioration and increased mortality. Empiric treatments, namely first and second-generation antipsychotics, confer modest efficacy in patients with AD and with psychosis (AD+P) and themselves increase mortality. Recent studies suggested the use and beneficial effects of antidepressants among patients with AD+P. This motivates our rationale for exploring their potential as a novel combination therapy option among these patients. We included electronic medical records of 10,260 patients with AD in our study. Survival analysis was performed to assess the effects of the combination of antipsychotics and antidepressants on the mortality of these pati

SUBMITTER: Fan P 

PROVIDER: S-EPMC10431054 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature