Accurate method for value assignment of carcinoembryonic antigen reference materials.

ABSTRACT:

Background

In this study, we explored the commutability of reference materials (RMs) for carcinoembryonic antigen (CEA), selected the appropriate diluent matrix of the first International Reference Preparation (IRP) 73/601 of the World Health Organization (WHO 73/601) for CEA, and improved the comparability of CEA measurement results among different assay systems.

Methods

Forty serum samples were divided into five aliquots. WHO 73/601 was diluted into nine concentrations using five diluents with different components, and the candidate RMs for CEA at five concentrations (C1-C5) were prepared by the Beijing Clinical Laboratory Center (BCCL). The samples were analyzed via five automated CEA immunoassays.

Results

Carcinoembryonic antigen candidate RMs were commutable amon

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10431395 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature