Genetic and healthy lifestyle factors in relation to the incidence and prognosis of severe liver disease in the Chinese population.

ABSTRACT:

Background

Severe liver disease (SLD), including cirrhosis and liver cancer, constitutes a major disease burden in China. We aimed to examine the association of genetic and healthy lifestyle factors with the incidence and prognosis of SLD.

Methods

The study population included 504,009 participants from the prospective China Kadoorie Biobank aged 30-79 years. The individuals were from 10 diverse areas in China without a history of cancer or liver disease at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for incident SLD and death after SLD diagnosis associated with healthy lifestyle factors (smoking, alcohol, physical activity, and central adiposity). Additionally, the contribution of genetic risk for hepatitis B virus (HBV, assessed by genetic var

SUBMITTER: Pang Y 

PROVIDER: S-EPMC10431401 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature