PAI-1 genetic polymorphisms influence septic patients' outcomes by regulating neutrophil activity.

ABSTRACT:

Background

Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathophysiology of sepsis, but the exact mechanism remains debatable. In this study, we investigated the associations among the serum levels of PAI-1, the incidence of 4G/5G promoter PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients.

Methods

A total of 181 patients aged 18-80 years with sepsis between November 2016 and August 2018 in the intensive care unit in the Xinhua Hospital were recruited in this retrospective study, with 28-day mortality as the primary outcome. The initial serum level of PAI-1 and the presence of rs1799768 single nucleotide polymorphisms (SNPs) were examined. Univariate logistic regression and multivariate analyses were perfor

SUBMITTER: Jiang S 

PROVIDER: S-EPMC10431590 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature