Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala.

ABSTRACT: Strong evidence has implicated ubiquitin signaling in the process of fear memory formation. While less abundant than ubiquitination, evidence suggests that protein SUMOylation may also be involved in fear memory formation in neurons. However, the importance of amygdala protein SUMOylation in fear memory formation has never been directly examined. Furthermore, while recent evidence indicates that males and females differ significantly in the requirement for ubiquitin signaling during fear memory formation, whether sex differences also exist in the importance of protein SUMOylation to this process remains unknown. Here we found that males and females differ in the requirement for protein SUMOylation in the amygdala during fear memory formation. Western blot analysis revealed that while femal

SUBMITTER: Gustin A 

PROVIDER: S-EPMC10431910 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature