Oral and gut microbial biomarkers of susceptibility to respiratory tract infection in adults: A feasibility study.

ABSTRACT: We conducted a feasibility cohort study which aimed to recruit and retain adults from the community to collect saliva (oral) and stool (gut) samples at three time points, at the start of the study (baseline), during a respiratory tract infection (RTI) and post-RTI. Community RTIs place a huge burden on health care services, and a non-invasive microbial diagnostic tool to predict the most vulnerable to respiratory infection would be ideal. To this aim, we analysed oral-gut baseline samples comparing those who reported RTI symptoms to those who remained healthy throughout the study for microbial biomarkers of respiratory susceptibility. Amplicon sequence variants (ASV) were identified by 16S sequence profiling to reveal oral-gut microbes. Reverse transcriptase-polymerase chain reaction (RT-P

SUBMITTER: Woodall CA 

PROVIDER: S-EPMC10432180 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature