Small-angle x-ray scattering investigation of the integration of free fatty acids in polysorbate 20 micelles.

ABSTRACT: A critical quality attribute for liquid formulations is the absence of visible particles. Such particles may form upon polysorbate hydrolysis resulting in release of free fatty acids into solution followed by precipitation. Strategies to avoid this effect are of major interest for the pharmaceutical industry. In this context, we investigated the structural organization of polysorbate micelles alone and upon addition of the fatty acid myristic acid (MA) by small-angle x-ray scattering. Two complementary approaches using a model of polydisperse core-shell ellipsoidal micelles and an ensemble of quasiatomistic micelle structures gave consistent results well describing the experimental data. The small-angle x-ray scattering data reveal polydisperse mixtures of ellipsoidal micelles containing a

SUBMITTER: Ehrit J 

PROVIDER: S-EPMC10432221 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature