Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease: the debate continues.

ABSTRACT: Crohn's disease (CD) in humans and Johne's disease (JD) in ruminants share numerous clinical and pathologic similarities. As Mycobacteria avium subspecies paratuberculosis (MAP) is known to fulfill Koch's postulates as the cause of JD, there has been considerable debate over the past century about whether MAP also plays a role in CD. With recent advances in MAP identification techniques, we can now demonstrate a higher presence of MAP in CD patients compared to the general population. However, it remains unclear if MAP is playing a bystander role or is directly pathogenic in these patients. Studies have shown that there may be an immune response targeting MAP in these patients, which may underlie a pathologic role in CD. Clinical studies have yielded conflicting results as to

SUBMITTER: Mintz MJ 

PROVIDER: S-EPMC10432229 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature