Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

ABSTRACT: The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological underpinnings; however, aging-related endpoints have been primarily assessed individually. Using data from these traits and multivariate genome-wide association study methods, we modeled their underlying genetic factor ('mvAge'). mvAge (effective n = ~1.9 million participants of European ancestry) identified 52 independent variants in 38 genomic loci. Twenty variants were novel (not reported in input genome-wide association studies). Transcriptomic imputation identified age-relevant genes, including VEGFA and PHB1. Drug-target Mendelian randomization with metformin target genes showed a beneficial impact on mvAge (P v

SUBMITTER: Rosoff DB 

PROVIDER: S-EPMC10432278 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature