LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples.

ABSTRACT:

Background

Breast cancer is the most commonly detected cancer and one of the leading causes of cancer mortality. Emerging evidence supports that aberrant expression of lncRNAs is correlated with tumor progression and various aspects of tumor development.

Aim

This study aimed to evaluate the expression pattern of LINC01116 in breast cancer tissues and investigate the impact of LINC01116 on patients' survival.

Methods and results

Microarray and qRT-PCR data analysis were performed, and the KM-plotter database was used in this study. In addition, the gain of function approach was performed to examine the effect of LINC01116 on breast cancer cells in-vitro. The results exhibited that LINC01116 is meaningfully upregulated in the ER+ tumor specimens compared to the ER- ones

SUBMITTER: Karimi Taheri M 

PROVIDER: S-EPMC10432450 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature