Estimating SARS-CoV-2 infections and associated changes in COVID-19 severity and fatality.

ABSTRACT:

Background

The difficulty in identifying SARS-CoV-2 infections has not only been the major obstacle to control the COVID-19 pandemic but also to quantify changes in the proportion of infections resulting in hospitalization, intensive care unit (ICU) admission, or death.

Methods

We developed a model of SARS-CoV-2 transmission and vaccination informed by official estimates of the time-varying reproduction number to estimate infections that occurred in Italy between February 2020 and 2022. Model outcomes were compared with the Italian National surveillance data to estimate changes in the SARS-CoV-2 infection ascertainment ratio (IAR), infection hospitalization ratio (IHR), infection ICU ratio (IIR), and infection fatality ratio (IFR) in five different sub-periods associated wit

SUBMITTER: Marziano V 

PROVIDER: S-EPMC10432583 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature