Cyclo(His-Pro): A further step in the management of steatohepatitis.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has been approved. The naturally occurring compound cyclo histidine-proline (His-Pro) (CHP) is an interesting candidate for NAFLD management, given its safety profile and anti-inflammatory effects.

Methods

Two different mouse models of liver disease were used to evaluate protective effects of CHP on disease progression towards fibrosis: a model of dietary NAFLD/NASH, achieved by thermoneutral housing (TN) in combination with feeding a western diet (WD), and liver fibrosis caused by repeated injections with carbon tetrachloride (CC

SUBMITTER: De Masi A 

PROVIDER: S-EPMC10432811 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature