A reliable QSPR model for predicting drug release rate from metal-organic frameworks: a simple and robust drug delivery approach.

ABSTRACT: During the drug release process, the drug is transferred from the starting point in the drug delivery system to the surface, and then to the release medium. Metal-organic frameworks (MOFs) potentially have unique features to be utilized as promising carriers for drug delivery, due to their suitable pore size, high surface area, and structural flexibility. The loading and release of various therapeutic drugs through the MOFs are effectively accomplished due to their tunable inorganic clusters and organic ligands. Since the drug release rate percentage (RES%) is a significant concern, a quantitative structure-property relationship (QSPR) method was applied to achieve an accurate model predicting the drug release rate from MOFs. Structure-based descriptors, including the number of nitrogen an

SUBMITTER: Tayebi L 

PROVIDER: S-EPMC10432896 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature