Bilayer vascular grafts with on-demand NO and H₂S release capabilities.

ABSTRACT: Nitric oxide (NO) and hydrogen sulfide (H₂S) gasotransmitters exhibit potential therapeutic effects in the cardiovascular system. Herein, biomimicking multilayer structures of biological blood vessels, bilayer small-diameter vascular grafts (SDVGs) with on-demand NO and H₂S release capabilities, were designed and fabricated. The keratin-based H₂S donor (KTC) with good biocompatibility and high stability was first synthesized and then electrospun with poly (l-lactide-co-caprolactone) (PLCL) to be used as the outer layer of grafts. The electrospun poly (ε-caprolactone) (PCL) mats were aminolyzed and further chelated with copper (II) ions to construct glutathione peroxidase (GPx)-like structural surfaces for the catalytic generation of NO, which acted as the i

SUBMITTER: Li P 

PROVIDER: S-EPMC10432902 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature