Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques

ABSTRACT: The network formed by the amygdala (AMG) and the medial Prefrontal Cortex (mPFC), at the interface between our internal and external environment, has been shown to support some important aspects of behavioral adaptation. Whether and how the anatomo-functional organization of this network evolved across primates remains unclear. Here, we compared AMG nuclei morphological characteristics and their functional connectivity with the mPFC in humans and macaques to identify potential homologies and differences between these species. Based on selected studies, we highlight two subsystems within the AMG-mPFC circuits, likely involved in distinct temporal dynamics of integration during behavioral adaptation. We also show that whereas the mPFC displays a large expansion but a preserved intrinsic anat

SUBMITTER: Giacometti C 

PROVIDER: S-EPMC10432920 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature