A novel microRNA panel exhibited significant potential in evaluating the progression of laryngeal squamous cell carcinoma.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the head and neck in humans. The 5-years survival rate of patients with LSCC have declined in the past four decades. microRNAs (miRNAs) has been reported to be capable of predicting the prognosis outcomes of patients with different cancers. However, there are no reports on the usage of multi-miRNAs model as signature for the diagnosis or prognosis of LSCC.

Methods

To establish the miRNAs expression-associated model for diagnosis, prognosis prediction and aided therapy of patients with LSCC, the present study enrolled 107 patients with LSCC in clinic and obtained 117 LSCC samples data from TCGA database for evaluation, respectively. Next generation sequencing (NGS), raw data processing, the least absolu

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10432973 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature