Luteolin and triptolide: Potential therapeutic compounds for post-stroke depression via protein STAT.

ABSTRACT: Post stroke depression (PSD) is a common neuropsychiatric complication following stroke closely associated with the immune system. The development of medications for PSD remains to be a considerable challenge due to the unclear mechanism of PSD. Multiple researches agree that the functions of gene ontology (GO) are efficient for the investigation of disease mechanisms, and DeepPurpose (DP) is extremely valuable for the mining of new drugs. However, GO terms and DP have not yet been applied to explore the pathogenesis and drug treatment of PSD. This study aimed to interpret the mechanism of PSD and discover important drug candidates targeting risk proteins, based on immune-related risk GO functions and informatics algorithms. According to the risk genes of PSD, we identified 335 immune-rela

SUBMITTER: Zhao T 

PROVIDER: S-EPMC10432979 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature