Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts.

ABSTRACT:

Background

Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.

Methods

Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.

Findings

We found a distinct non-linear association between temperature a

SUBMITTER: Timpka S 

PROVIDER: S-EPMC10432996 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature