Highly recruited brown adipose tissue does not in itself protect against obesity.

ABSTRACT:

Objective

The possibility to counteract the development of obesity in humans by recruiting brown or brite/beige adipose tissue (and thus UCP1) has attracted much attention. Here we examine if a diet that can activate diet-induced thermogenesis can exploit pre-enhanced amounts of UCP1 to counteract the development of diet-induced obesity.

Methods

To investigate the anti-obesity significance of highly augmented amounts of UCP1 for control of body energy reserves, we physiologically increased total UCP1 amounts by recruitment of brown and brite/beige tissues in mice. We then examined the influence of the augmented UCP1 levels on metabolic parameters when the mice were exposed to a high-fat/high-sucrose diet under thermoneutral conditions.

Results

The total UCP1 levels ac

SUBMITTER: von Essen G 

PROVIDER: S-EPMC10432997 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature