Reversible rearrangement of the cellular cytoskeleton: A key to the broad-spectrum antiviral activity of novel amphiphilic polymers.

ABSTRACT: The battle against emerging viral infections has been uneven, as there is currently no broad-spectrum drug available to contain the spread of novel pathogens throughout the population. Consequently, the pandemic outbreak that occurred in early 2020 laid bare the almost empty state of the pandemic box. Therefore, the development of novel treatments with broad specificity has become a paramount concern in this post-pandemic era. Here, we propose copolymers of poly (sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and poly (sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS₇₅-b-PAaU_n) and random (P(AMPS_m-co-AaU_n)) that show efficacy against a broad range of alpha and betacoronaviruses. Owing to their intricate architecture, these p

SUBMITTER: Dabrowska A 

PROVIDER: S-EPMC10433002 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature