Asynchronous axonal firing patterns evoked via continuous subthreshold kilohertz stimulation.

ABSTRACT: Objective.Transcutaneous electrical stimulation of peripheral nerves is a common technique to assist or rehabilitate impaired muscle activation. However, conventional stimulation paradigms activate nerve fibers synchronously with action potentials time-locked with stimulation pulses. Such synchronous activation limits fine control of muscle force due to synchronized force twitches. Accordingly, we developed a subthreshold high-frequency stimulation waveform with the goal of activating axons asynchronously.Approach.We evaluated our waveform experimentally and through model simulations. During the experiment, we delivered continuous subthreshold pulses at frequencies of 16.67, 12.5, or 10 kHz transcutaneously to the median and ulnar nerves. We obtained high-density electromyogr

SUBMITTER: Vargas L 

PROVIDER: S-EPMC10433012 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature